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應用教學

你知道嗎?天天運動可以改善神經退化性疾病的症狀!

NOV 05 ,2021

這是一個令人振奮的消息!來自三軍總醫院的陳元皓醫師與美國Case Western 大學的Hoffer博士,這兩人所帶領的團隊在Nature旗下的Scientific Reports期刊發表了一篇研究,內容是有關於透過運動改善巴金森氏症動物的症狀與內分泌功能。

 

47302 d                 47750 leaflet

 

他們使用了來自 UGO BASILE 的 大小鼠通用跑步機 以及 大鼠滾輪測試儀 Rotarod ,在實驗設計中他們對已患有巴金森式症的老鼠使用了這兩款儀器進行訓練,並且得到了令人滿意的結果。接受過跑步機運動訓練的老鼠們不論是在Rotarod滾輪的表現還是行走速度上都獲得了顯著的改善,運動同時也改善了動物無法直線行走的問題。

 

以下為此篇研究摘要與數據範例,有興趣的人亦可免費下載整篇文章 Y.H Chen et alia: SCIENTIFIC REPORTS (2018) 8:3973

 

To determine the influences of exercise on motor deficits and dopaminergic transmission in a hemiparkinson animal model, we measured the effects of exercise on the ambulatory system by estimating spatio-temporal parameters during walking, striatal dopamine (DA) release and reuptake and synaptic plasticity in the corticostriatal pathway after unilateral 6-OHDA lesions. 6-OHDA lesioned hemiparkinsonian rats were exercised on a fixed speed treadmill for 30 minutes per day. Controls received the same lesion but no exercise. Animals were subsequently analyzed for behavior including gait analysis, rotarod performance and apomorphine induced rotation. Subsequently, in vitro striatal dopamine release was analyzed by using FSCV and activity-dependent plasticity in the corticostriatal pathway was measured in each group. Our data indicated that exercise could improve motor walking speed and increase the apomorphine-induced rotation threshold. Exercise also ameliorated spatiotemporal impairments in gait in PD animals. Exercise increased the parameters of synaptic plasticity formation in the corticostriatal pathway of PD animals as well as the dynamics of dopamine transmission in PD animals. Fixed speed treadmill training 30 minutes per day could ameliorate spatial-temporal gait impairment, improve walking speed, dopamine transmission as well as corticostriatal synaptic plasticity in the unilateral 6-OHDA lesioned rat model.

 

Scientific Report 2018 8 3973

 

figure1

Exercise could improve walking speed, rotarod coordination and reduce supersensitivity of apomorphine –induced rotation in PD animals. Motor behavior tests were performed for 4 weeks after 6-OHDA lesions and data were obtained from a comparison between PD and PD with exercise animals. (A) Apomorphine-induced rotation was used to confirm that the 6-OHDA lesion induced hemi-parkinsonism; there was no significant difference between PD and PD with exercise with apomorphine initially. (B) There were no differences in body weight between groups. (C) The rotarod test revealed that the short retention time in PD animals could be lengthened by exercise. (D) The data from the rotarod of each group from post-lesion 2nd to 5th weeks were averaged and ploted. (E) The walking speed improved gradually during exercise training and significant improvement could be found after four-weeks of exercise. (F) The data on walking speed of each group from post-lesion 2nd to 5th weeks were averaged and ploted. (G–H) the apomorphine-induced rotation data showing reduced supersensitivity in the PD exercise group.