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實驗動物活體腦部電位快速掃描系統 Fast Scan CyclicC Voltametry System

產品型號: FSCV
廠牌名稱: Pinnacle Technology
FSCV為一種可透過電位變化即時偵測出兒茶酚胺類物質含量的最新技術, Pinnacle Technology將這樣的技術商品化, 提供您一個腦內啡相關研究的絕佳設備, 此系統包含了有線與無線系統可供選擇, 且可搭配Biosensor或EEG/EMG系統使用

產品特點

FSCV系統,全名為Fast Scan Cyclic Voltammetry system,是一種用於偵測兒茶酚胺類化合物(例如多巴胺dopamine, 正腎上腺素norepinephrine等) 的技術,同時也可以用來偵測一些具有電活性的小分子(例如adenosine腺苷),每一種小分子活化時都會有獨特的電位變化,Pinnacle Technology的FSCV系統透過特製的碳纖維電極進行這些電活性小分子的微小電位變化,顯示出各種不同的波型來得知各類型分子的活性。

隨附的數據收集/分析軟體可以幫忙您快速的分析 dopamine, norepinephrine, serotonin 以及 adenosine 這四種分子,但軟體亦可視使用者的需要隨時擴充不同分子的波型。

 

Pinnacle Technology的FSCV系統包括了有線系統與無線系統,無線系統僅能使用在大鼠上。

無論是有線還是無線系統,皆具有接收外部訊號以及透過外部訊號觸發系統的功能。

 

Pinnacle's robust, turn-key FAST SCAN CYCLIC VOLTAMMETRY (FSCV) SYSTEM is designed to simplify the measurement of catecholamines (i.e., dopamine, norepinephrine, etc.) and other electroactive analytes such as adenosine. It functions by rapidly cycling a voltage across an implanted carbon fiber sensor and measuring the resultant current. Both the tethered system for mice and rats and the wireless system for rats have built-in support for controlling an external stimulus. The system ships with Pinnacle's FSCV software.

 

Preprogrammed and Custom Waveforms

The FSCV software offers preprogrammed waveforms associated with the commonly studied analytes: dopamine, norepinephrine, serotonin and adenosine. Custom waveforms can be easily uploaded as well, and stored in a drop-down menu for quick selection.

 

Analysis

A graph showing signature waveforms for dopamine, serotonin and norepinephrine.

Dopamine (blue), serotonin (green), and norepinephrine (red) display specific voltammogram profiles when detected by FSCV.

 

產品規格

HOW IT WORKS

Changes in analyte concentration are detected by rapidly cycling a voltage across an implanted carbon fiber sensor and measuring the resultant current. Pinnacle's FSCV system can measure spontaneous sub-second neurotransmitter release while conducting detailed behavioral studies. Both the wireless and tethered systems scan up to 1,000 V/s in a user-selectable range spanning -0.6 to +1.5 V. All systems have built-in support for controlling an external stimulus.

Key Features

  • Image bullet Voltage Span: -0.6 V to +1.5 V
  • Image bullet Max scan rate: 1,000 V/s
  • Image bullet Max sweeps/second: 10
  • Image bullet Max points/sweep: 1,000 

3-D heat map of reduction/oxidation measurement data

CARBON FIBER ELECTRODES

Detail of a carbon fiber sensor

Pinnacle's FSCV system uses CARBON FIBER ELECTRODES (CFEs) to measure the presence of dopamine and other catecholamines in the brains of freely moving animals. All Pinnacle CFSs require an Ag/AgCl reference electrode.

 

CALIBRATION

In order to relate the current changes measured by a sensor to actual changes in concentration, it is necessary to calibrate the sensor at the conclusion of an experiment. This process also confirms the integrity and selectivity of the sensor.

FSCV SOFTWARE PACKAGE

The FSCV system includes Pinnacle's FREE FSCV software, which supports traditional, short recording paradigms (recordings of two minutes or less) as well as longer-term recordings that use an extended continuous mode. Furthermore, the suite supports integrated, synchronized video recording, which allows monitoring of animal behavior simultaneously with biogenic amine release.

 

  • Features include:
  • •  Background subtraction
  • •  3-D visualization
  • •  User-selectable filters
  • •  Heat maps
  • •  Preprogrammed and custom waveforms
  • •  Import/export to third-party packages

 

 

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