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肌細胞培養測量系統 Intact Muscle Chamber System

產品型號:
廠牌名稱: IonOptix
介於單一細胞和離體心臟系統之間,從心臟中分離出完整的乳頭肌具有獨特的優勢。

產品特點

與最小功能模型系統-單一孤立肌細胞不同,完整的乳頭肌可用於在多細胞環境和完整的 3 D肌肉束中研究心臟功能。與分離心臟研究不同,乳頭頭肌的收縮特性可以排除於血管張力等外在因素進行測量。乳頭肌也可以實行在整個心臟中太難或不可能的實驗。同樣,與剝了皮的樣本不同,完整的肌肉樣本允許同時檢測力的產生和細胞內鈣離子動力學。

  • 在肌肉束樣本中同時測量收縮力以及鈣離子濃度
  • 適合各種肌肉(papillary muscle, trabeculae, EDL, soleus..等)
  • 高度精密馬達測量肌肉拉力
  • 可程序化長度步驟

產品規格

完整的肌肉腔系統可以與肌細胞收縮與鈣離子測量系統相結合,以提供全套同步螢光和收縮性(即力量發展)測量。

Microscope

IonOptix-configured inverted microscopes provide an ideal platform for combined photometry and dimensioning measurements. These microscopes have been engineered to incorporate various unique IonOptix optical components and connectors in order to operate as the imaging component within our Calcium and Contractility Systems. Choose between the Motic AE31 or the Olympus IX73 depending on your application.

Light Sources

The fluorescence excitation light source is chosen with your specific research needs in mind and can be configured for almost any dye or combination of dyes. Options include the ultra-fast HyperSwitch, monochromatic LEDs, or the more affordable MuStep.

Sensors

The sensors within the Calcium and Contractility system are responsible for translating cellular signal into data. Cell contractility is measured using the high-speed MyoCam-S3 digital camera, and whole-cell fluorescence photometry is measured with a photomultiplier tube (PMT). For cleaner fluorescence signals, the Cell Framing Adapter allows you to frame a cell of interest and reduce background fluorescence.

Force Transducer

The robust force transducer measures muscle force development with a typical sensitivity range of 0-100 mN.

Cell Stimulators

The field stimulator is an important component of excitation-contraction studies to provide acute stimulation of cells. Use either the MyoPacer for simple stimulation protocols or the MyoPacer EP for advanced sequencing and arrhythmic stimulation.

Tissue Chamber

The specially-designed muscle chamber allows for easy mounting of muscle strips on inert platinum hooks and inlet and outlet perfusion flow. It is compatible with almost any type of inverted microscope stage.

Fluorescence System Interface

The FSI ties the Calcium and Contractility system components together by communicating between hardware and the computer, allowing for synchronous control of contractility and/or calcium measurements as well as inputs and outputs for external devices.

Length Controller

Several options are available to tailor programmable length control to your studies based on length range, resolution, and frequency response. 

 

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