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產品資訊

CALCIUM AND CONTRACTILITY IN ISOLATED MYOCYTES - 肌肉細胞收縮與鈣離子量測系統

產品型號:
廠牌名稱:
• 即時記錄肌肉細胞收縮與鈣離子的轉鑰系統</br>
• 可與目前已知所有廠牌顯微鏡或影像系統結合</br>
• 可同時偵測螢光強度與螢光影像</br>
• 可得到細胞長度與肌節間距等數據</br>
• 超高採樣頻率:以1000Hz的採樣頻率同時收集4個頻道12位元的類比數據</br>
• 可直接經由軟體調整類比訊號放大倍率及初始值( gain & offset)</br>
• 可分析視野內任何區域影像,並可以由不同使用者自行定義不同擷取範圍</br>
• 所有參數皆可以獨立控制,包含sampling rate、averaging for image、zone、analog data within each sampling epoch</br>
• 事件標記可以透過外部TTL訊號、鍵盤或滑鼠</br>

產品特點

IonOptix is proud to offer fast real-time, turnkey systems for recording myocyte calcium and contractility.  We are unique in offering simultaneous acquisition of fluorescence photometry with digital cell geometry measurements.  All individual components are designed and engineered to work as part of a complete and integrated workstation. This approach enables precise, synchronous data acquisition.  The systems are fully integrated and installed on-site, so that the researcher can be up to speed within days of delivery. More than a general fluorescence system, our systems enable investigators to acquire cell length and sarcomere spacing with their calcium data.

Systems are offered with either of our two excitation light sources: the HyperSwitch or the µStep. Single, dual excitation and dual emission photometry is offered to cover all possible fluorescence probes with acquisition rates up to 1000Hz. Photometry acquisition rates are dependent on the light source and probe.  Our MyoCam-Sprovides up to 1000Hz cell dimension measurements, including simultaneous cell and sarcomere length recording. Our Fluorescence System Interface also permits the simultaneous acquisition of up to 4 channels of 12-bit analog data at a default rate of 1000Hz.

We can interface our system with an existing microscope or supply the microscope as part of the system. To provide a complete system for physiological measurements we also supply a number of peripheral items including digital field stimulators, chambers and heaters. Follow the link to find more information on these components.

As with all of our systems, we stand behind our products. When we install our complete systems we use your preparations to help get you started as quickly as possible. And when you need assistance we offer unlimited phone and email support for the lifetime of your system. Download the system description below for more information.

 

細胞收縮與離子濃度同步測定 

產品規格

  • HyperSwitch Light Source
  • µStep Light Source
  • PMT Sub-System
  • MyoPacer EP Cell Stimulator
  • IonWizard-Core and Analysis
  • SarcLen Sarcomere Length Acquisition Module
  • Fluorescence System Interface
  • MyoPacer Cell Stimulator
  • SoftEdge™ Myocyte Cell Length Acquisition Module
  • MyoCam-S
  • Photon-to-Voltage Converter
  • PMTAcq Fluorescence Photometry Acquisition Module

應用領域

Title Author(s) Journal
Adenosine A2A and {beta}-adrenergic calcium transient and contractile responses in rat ventricular myocytes James G. Dobson, Jr., Lynne G. Shea, Richard A. Fenton Am J Physiol Heart Circ Physiol, Oct 2008; 10.1152/ajpheart.00927.2008 ...
Ecstasy produces left ventricular dysfunction and oxidative stress in rats    
Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes U. Siedlecka, M. Arora, T. Kolettis, G. K. R. Soppa, J. Lee, M. A. Stagg, S. E. Harding, M. H. ... Am J Physiol Heart Circ Physiol, Nov 2008; 295: H1917 - H1926.
G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure Philip W. Raake, Leif E. Vinge, Erhe Gao, Matthieu Boucher, Giuseppe Rengo, Xiongwen Chen, Brent R. ... Circ. Res., Jul 2008; 10.1161/CIRCRESAHA.107.168336
High-fat Diet-induced Obesity Leads to Resistance to Leptin-induced Cardiomyocyte Contractile Response. High-fat Diet-induced Obesity Leads to Resistance to Leptin-induced Cardiomyocyte Contractile ... Am J Physiol Heart Circ Physiol, Nov 2008; 295: H1917 - H1926
Hypertrophic Cardiomyopathy in High Fat Diet-Induced Obesity: Role of Suppression of Forkhead Transcription Factor and Atrophy Gene Transcription Cindy X Fang, Feng Dong, D. Paul Thomas, Heng Ma, Leilei He, Jun Ren Am J Physiol Heart Circ Physiol (July 18, 2008). doi:10.1152/ajphear ...
Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure Younss Aït Mou, Cyril Reboul, Lucas Andre, Alain Lacampagne, Olivier Cazorla Am J Physiol Lung Cell Mol Physiol, Sep 2008; 10.1152/ajplung.00053.2008
Leptin Attenuates Cardiac Contraction in Rat Ventricular Myocytes : Role of NO Marvie W. Nickola, Loren E. Wold, Peter B. Colligan, Guei-Jane Wang, Willis K. Samson, and Jun R ... Hypertension, 36
Mitochondrial Matrix Metalloproteinase Activation Decreases Myocyte Contractility in Hyperhomocysteinemia Karni S Moshal, Srinivas M. Tipparaju, Thomas P Vacek, Munish Kumar, Mahavir Singh, Iluiana E ... Am J Physiol Heart Circ Physiol, Jun 2008; 10.1152/ajpheart.00099.2008
Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T Xi-Yuan Lu, Le Chen, Xiao-Long Cai, Huang-Tian Yang Cardiovasc Res, Aug 2008; 79: 500 - 508
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload John A. Muraski, Kimberlee M. Fischer, Weitao Wu, Christopher T. Cottage, Pearl Quijada, Matt ... NAS, Sep 2008; 10.1073/pnas.0709135105.

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