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新款被動迴避-逐降法 Passive Avoidance (Step Down)

產品型號: 40570
廠牌名稱: Ugo basile
被動迴避Step-Down又稱跳台實驗。與一般的俗稱的黑白箱實驗不同,跳台實驗的箱體只有一個隔間。此箱的地板為無差別的可通電金屬網所構成,中間則為一個不帶電的平台,將動物放在該平台上後開始實驗,然而此平台會開始晃動使得站在上面的動物產生不悅感,但若動物選擇跳離平台即會遭受電擊,動物將在被電或忍受震動的雙重刺激下做出抉擇。

產品特點

  • 專對不討厭光亮環境的動物所設計,例如幼鼠
  • 震動與電刺激強度皆可調整
  • 包含中控平板電腦,無需額外連接電腦設備
  • 中控電腦與旗下諸多行為儀器共用,未來擴充設備只需額外添購箱體

 

被動迴避 Step-Down 又稱跳台實驗。與一般的Step through 法 (俗稱的黑白箱) 實驗不同,跳台實驗的箱體只有一個隔間。

 

此箱的地板為無差別的可通電金屬網所構成,中間則為一個不帶電的平台,將動物放在該平台上後開始實驗,然而此平台會開始晃動使得站在上面的動物產生不悅感,但若動物選擇跳離平台即會遭受電擊,動物將在被電或忍受震動的雙重刺激下做出抉擇。

 

針對不畏光的動物來說,使用Step-Down設備進行實驗會比Step-Through更有顯著差異。

 

A classic way to assess short or long-term memory in small laboratory animals (rodents) using a fear-motivated avoidance task. Used routinely in animal model studies of aging and Alzheimer-type dementia, including the search for new therapeutic drugs.

An efficient, reliable instrument for use with mice (or small rats). A silent, automated sliding door divides compartments. Precision 8-pole shocker.

 

Background

  • Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal learns to avoid, and an aversive stimulus, represented by a mild foot shock. 
  • Conduct tests in our two-compartment apparatus, in which one is dimly lit and preferable to a rodent, and the other is brightly lit.

Efficient, flexible, easy to set up and manage

  • Our Passive Avoidance set-up comprises: 
    • A mouse cage with one controller for up to 4 cages.
    • 2 compartments: START which is light and illuminated. ESCAPE, which is dark with a grid floor, connected to a constant-current high precision 8-pole shocker.
    • Silent, automated sliding door dividing compartments. Opens at pre-set delay and enables the latency timer that tracks time of animal crossing.
    • Tilting floor provides a simple and reliable detection mechanism to score the animal’s movement across the two compartments.
    • Versatile Controller with 12” touch-screen for managing your Passive and Active Avoidance tests. 
  • Multiple configurations can be controlled by the large touch-screen.
  • Data is recorded, displayed and stored in the control unit. Transfer test data to your PC using the USB key (supplied) for further processing using Excel, Access, etc. 
  • Optional expansion box (extra) can connect up to 4 cages to the same Controller.
  • Part of the expandable, convenient Beehive Cage-Manager system. Use one touch screen controller to control and manage all of your Ugo Basile cages. Ask for details!

產品規格

Touch Screen Controller
LCD 12” with resistive touch screen
CPU Module Port 2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor
Peripheral Port 4 output for Sound, Shock and  light; 1 Power supply 12V-2A
Expansion Bus         Connection 2 RJ11 connectors
General  
Shock Constant current
Shock Intensity from 0 to 3mA, in 0.1mA steps
Platform Vibration 10-100Hz, in 10Hz steps
Vibration Width 0-10, in steps of 1
Vibration Delay 0-15 seconds, in 1s steps
Operating Temperature 10° to 40°C
Sound Level Negligible
Pollution Degree ≤ 2
Number of Cages Up to 4 (with expansion boxes)
Physical  
Dimensions

25(d)x33(w)x5.5(h)cm (40500-001)

28(w)x23(d)x26(h)cm (40573)

Weight

2.7Kg (40500-001)

3.5 (40573)  

Shipping Weight

4Kg (40500-001)

6Kg (40573)

Packing Dimensions 80x60x44cm (Control Unit & one cage)

應用領域

Behavioral scientists are well acquainted with passive avoidance methods that have been used for several decades, originally by psychologists, who were interested in animal behavior.

These procedures were later exploited by neuroscientists, who specifically perform sys-tematic studies of the behavioral changes mainly produced by brain lesions, to define the functions of different C.N.S. sections.

The Passive Avoidance was soon extended to several other areas of research such as behavior genetics, psychopharmacology and behavioral toxicology.

More recently, such use has become routine in animal model studies of aging and of Alz-heimer-type dementia, including the search for new drugs of potential therapeutic value, consisting of attenuation of behavioral deficits.

The Passive Avoidance task is a one trial fear-motivated avoidance task, classically used to assess short-term or long-term memory on small laboratory animals (rodents).

Passive Avoidance is a broad term that includes an ample selection of methods and an equally wide variety of different versions of each method.

In our Passive Avoidance instrument one exploits the tendency to step down from a vi-brating, hence definitely uncomfortable floor section.

 

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