產品資訊
產品資訊
老鼠行為活動觀測箱 PhenoTyper
產品型號:
廠牌名稱: Noldus
老鼠行為活動觀測箱PhenoTyper 是一個進行實驗鼠行為觀察實驗的理想硬體設備，每一個箱體都包含了裝有日夜兩用光源以及攝影機的上蓋，以及下半部的觀測箱主體，箱體本身還可以再安裝燈光或聲音等刺激器。
▪ 光源與攝影機皆已優化，可錄製理想的實驗影像
▪ 可套用在多種行為實驗上
▪ 可搭配其他硬體設備與軌跡追蹤軟體使用
產品特點
PhenoTyper 尺寸選項與功能
PhenoTyper 提供兩種標準尺寸：PhenoTyper 3000 的底板面積為 30cm×30cm（12inch×12inch），而 PhenoTyper 4500 的底板面積為 45cm×45cm（18inch×18inch）。此外也支援客製化尺寸，例如在某些研究中曾使用 90cm×90cm（36inch×36inch）的模型。
設備頂部的單元配備一個紅外線敏感攝影機和三組紅外線 LED 燈。您可以透過實驗調整光照條件，例如建立晝夜循環、利用單一色調進行操作制約測試，或使用白光聚光燈進行趨近-迴避行為測試。
PhenoTyper 與社交互動
PhenoTyper 系統非常適合用於詳細研究社交互動。您甚至可以根據動物的行為觸發刺激。舉例來說，當動物們在同一區域時釋放食物獎勵，或者當牠們同時按下一個槓桿時。這些實驗流程都能透過 EthoVision XT 輕鬆實現自動化。
PhenoTyper 與操作制約
PhenoTyper 是進行操作制約測試的理想選擇。搭配 EthoVision XT，可以輕鬆將實驗流程自動化。例如，當小鼠進入某個區域時打開燈光，在大鼠按下槓桿後給予食物獎勵，或者在活動輪轉動一定次數後啟動煞車。您還可以連接多種操作模組到 PhenoTyper 籠子，例如自動發出氣流或給予食物獎勵。
如何擴充您的 PhenoTyper 設置？
PhenoTyper 可以根據您的研究需求進行客製化。PhenoTyper 提供了多種尺寸和各式各樣的附加配件。例如：顆粒餵食器、庇護所、跑步輪或光遺傳學設備。您可以透過這些附加配件頁面，探索所有能讓您的 PhenoTyper 更個人化的方式。
PhenoTyper 與焦慮測試
在 PhenoTyper 中，您可以使用溫和的厭惡性刺激進行焦慮測試。例如，當動物進入某個特定區域時自動打開燈光，或在黑暗期中當動物進食或飲水一段時間後點亮食物盒。此外，您也可以為 PhenoTyper 裝備一個可發光的庇護所，並透過 EthoVision XT 的 Trial & Hardware Control 模組進行控制。如此一來，當動物進入庇護所或選擇特定入口時，燈光就會自動亮起。您可以擴充設置，搭配其他 TTL 驅動的硬體，完全根據您的需求調整焦慮測試。
應用領域
Recent publications
- Mul, J.D.; Boxtel, R. van; Bergen, D.J.M.; Brans, M.A.D.; Brakke, J.H.; Toonen, P.W.; Garner, K.M.; Adan, R.A.H.; Cuppen, E. (2011). Melanocortin Receptior 4 Deficiency Affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity, doi: 10.1038/oby.2011.81.
- Olivier, J.D.A.; Valles, A.; Heesch, van, F.: Afrasiab-Middelman, A.; Roelofs, J.P.M.; Jonkers, M.; Peters, E.J.; Korte-Bouws, G.A.H.; Dederen, J.P.; Kiliaan, A.J.; Martens, G.J.; Schubert, D.; Homberg, J.R. (2011). Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. Psychopharmacology, doi10.1007/s00213-011-2299-z.
- Paradiso, B.; Zucchini, S.; Su, T.; Bovolenta, R.; Berto, E.; Marconi, P.; Marzola, A.; Navarro Mora, G.; Fabene, P.F.; Simonato, M. (2011). Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. Epilepsia, 52, 572-578.
- Schipper, P.; Nonkes, L.J.P.; Karel, P.; Kiliaan, A.J.; Homberg, J.R. (2011). Serotonin transporter genotype x construction stress interaction in rats. Behavioural Brain Research, 223, 169-175.
- Trent, S.; Dennehy, A.; Richardson, H.; Ojarikre, O.A.; Burgoyne, P.S.; Humby, T.; Davies, W. (2011). Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder. Psychoneuroendocrinology, doi:10.1016/j.psyneuen.2011.06.006.
- Valor, L.M.; Pulopulos, M.M.; Jimenez-Minchan, M.; Oliveras, R.; Lutz, B.; Barco, A. (2011). Ablation of CBP in Forebrain Principal Neurons causes modest memory and Transcriptional Defects and a dramatic reduction of Histone acetylation but does not affect cell viability. Journal of Neuroscience, 31, 1652-1663.
- Mooij-van Malsen, J.D. de: Vinkers, C.H.; Peterse, D.P.; Olivier, B.; Kas, M.J.H (2010). Cross-species behavioural genetics: A starting point for unravelling the Neurobiology of human psychiatric disorders. Neuro-Psychopharmacology & Biological Psychiatry, doi:10.1016/j.pnpbp.2010.10.003.
- Kang, J.; Kang, N.; Yu, Y.; Zhang, J.; Petersen, N.; Tian, G.F.; Nedergaard, M. (2010). Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal ca1 pyramidal neuroons. Neuroscience, 169, 1601-1609.
- Moscardo, E.; Rostello, C. (2010). An integrated system for video and telemetric electroencephalographic recording to measure behavioural and physiological parameters. Journal of Pharmacological and Toxicological Methods, 62, 64-71.
- Silverman, J.L.; Yang, M.; Lord, C.; Crawley, J.N. (2010). Behavioural phenotyping assays for mouse models of autism. Nature reviews neuroscience, 11, 490-502.
- Silverman, J.L.; Turner, S.M.; Barkan, C.L.; Tolu, S.S.; Saxena, R.; Hung, A.Y.; Sheng, M.; Crawley, J.N. (2010). Sociability and motor functions in Shank1 mutant mice. Brain research, 1380, 120-137.
- Kalueff, A.V.; Olivier, J.D.A.; Nonkes, L.J.P.; Homberg, J.R. (2010). Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neuroscience and Biobehavioral Reviews, 34, 373-386.
- Balemans, M.C.M.; Huibers, M.M.H.; Eikelenboom, N.W.D.; Kuipers, A.J.; Summeren, R.C.J. van; Pijpers, M.M.C.A.; Tachibana, M.; Shinkai, Y.; Bokhoven, H. van; Van der Zee, C.E.E.M. (2009). Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice. Behaviour Brain Research, article in press, doi: 10.1016/j.bbr.2009.11.008.
- Dalm, S.; Visser, L. de; Spruijt, B.M.; Oitzl, M.S. (2009). Repeated rat exposure inhibits the circadian activity patterns of C57BL/6J mice in the home cage. Behavioural Brain Research, 196, 84-92.
- Lukkes, J.L.; Mokin, M.V.; Scholl, J.L.; Forster, G.L. (2009). Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses. Hormones and Behavior, 55, 248-256.
- Mooij-van Malsen, J.G. de; Lith, H.A. van; Oppelaar, H.; Hendriks, J.; Wit, M. de; Kostrzewa, E.; Breen, G.; Collier, D.A.; Olivier, B.; Kas, M.J. (2009). Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder. Biological Psychiatry, article in press, doi: 10.1016/j.biopsych.2009.06.016.
- Pham, J.; Cabrera, S.M.; Sanchis-Segura, C.; Wood, M.A. (2009). Automated scoring of fear-related behavior using EthoVision software. Journal of Neuroscience Methods, 178, 323-326.
- Ryan, B.C.; Young, N.B.; Crawley, J.N.; Bodfish, J.W.; Moy, S.S. (2009). Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain. Behavioural Brain Research, article in press, doi:10.1016/j.bbr.2009.11.031.
- Yang, M.; Clarke, A.M.; Crawley, J.N. (2009). Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. European Journal of Neuroscience, 29, 1663-1677.
- Smits, S.M.; Noorlander, C.W.; Kas, M.J.H.; Ramakers, G.M.J.; Smidt, M.P. (2008). Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice. European Journal of Neuroscience, 27, 388-395.