產品資訊
產品資訊
飲水測試系統 Lickometer Vogel Test
產品型號: 45100
廠牌名稱: Ugo basile
Ugo Basile飲水測試系統是一個多用途的設備，可作為基於軟體的舔儀使用，可運行飲水衝突實驗以及可用於評估抗焦慮藥物等。飲水衝突實驗時，動物被置於實驗箱中，喝水會受到電擊，處於動機上矛盾的情形中，它的舔水行為收到焦慮與抗焦慮藥物的影響。
飲水衝突測試一般分下列三個階段：初步等待，電擊階段，無電擊階段。實驗每個階段中，動物舔水次數和時間將被儀器記錄，電擊與無電擊階段可根據實驗方案基於時間等因素交替。實驗結束後，測試報告將自動生成。不使用電擊操作，該系統可作為軟體控制的舔儀使用。
每個階段的持續時間由操作員控制，可以根據時間，也可以根據動物行為控制（例如：在一定數量的舔水行為之後進行電擊。）
產品特點
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The Ugo Basile Lickometer - Vogel Test is a versatile system that can function as a simple software-based lickometer or run Drinking-Conflict experiments and assess the anxiolytic effect of drugs.
In the Drinking-Conflict Vogel paradigm, a water deprived animal is exposed to a lickometer, and licking events are coupled to electric shocks. The animal is in a motivationally conflicting situation, hence the licking behavior is affected by anxiety and anxiolytic drugs.
The Drinking Conflict Vogel test usually consists of three phases:
- Initial wait (triggered by the first licking event)
- Shock phase (the sipper is electrified)
- No-shock phase (no shock is associated to drinking)
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For each phase of the experiment, the number and the timing of licking events is recorded and graphically displayed. The alternation between shock and no-shock phase can be based on TIME or N° OF LICKS, according to the user experimental paradigm. When no shock is delivered, the system can be simply used as a software-driven lickometer.
The duration of each phase is user-defined for each cage based either on time or on the animal behaviour (i.e. the sipper is electrified after a defined number of licking events have occurred).
The Lickometer controller and software can manage up to 5 animal cages for either rat or mouse; one shocker is required for each cage.
The user-friendly software, provided as standard, manages the system and experimental configuration, collects and saves the experimental data, and provides a detailed report. Data are saved as .csv file and .rpt file (a proprietary format which can be opened only within the Lickometer software)
產品規格
| General | |
| Shock | 2-Pole Sine-Wave Shocker |
| Test Settings | Trial duration, Initial Pause, Time Intervals, Number of Licks to deliver a shock |
| Data Acquisition | via proprietary software |
| Data Format | Data are saved as .csv file and .rpt file (proprietary to Lickometer software) |
| Operating Temperature | 10° to 40°C |
| Sound Level | Negligible |
| Pollution Degree | ≤ 2 |
| Number of Cages | Up to 5 (one shocker for each cage is required) |
| Physical | |
| Dimensions |
35(w)x25(d)x30(h)cm (Rat Cage) 20(w)x24(d)x20(h)cm (Mouse Cage) |
| Weight |
8.5Kg (Rat Set-Up) 7.5Kg (Mouse Set-up) |
| Shipping Weight |
12Kg (Rat Set-Up) 10Kg (Mouse Set-up) |
| Packing Dimensions | 80x60x44cm (Control Unit, shocker & one cage) |
應用領域
The Vogel Conflict Test is a conflict based experimental method primarily used in pharmacology. It is used to determine anxiolytic properties of drugs. The Vogel Test predicts drugs that can manage generalized anxiety disorders and acute anxiety states.
Suppressing behaviour through punishment is commonly used to determine the anxiolytic properties of drugs. During the Vogetl Test, animals are receive electrical shocks when trying to get either water. Therefore the number of times the animal goes to get water decreases. When anxiolytic drugs are injected, the number of times animals go up to get water increases, even though the animal are still punished.