Ugo basile 飲水測試系統 45100 - Lickometer Vogel Test
The Ugo Basile Lickometer - Vogel Test is a versatile system that can function as a simple software-based lickometer or run Drinking-Conflict experiments and assess the anxiolytic effect of drugs.
In the Drinking-Conflict Vogel paradigm, a water deprived animal is exposed to a lickometer, and licking events are coupled to electric shocks. The animal is in a motivationally conflicting situation, hence the licking behavior is affected by anxiety and anxiolytic drugs.
The Drinking Conflict Vogel test usually consists of three phases:
- Initial wait (triggered by the first licking event)
- Shock phase (the sipper is electrified)
- No-shock phase (no shock is associated to drinking)
For each phase of the experiment, the number and the timing of licking events is recorded and graphically displayed. The alternation between shock and no-shock phase can be based on TIME or N° OF LICKS, according to the user experimental paradigm. When no shock is delivered, the system can be simply used as a software-driven lickometer.
The duration of each phase is user-defined for each cage based either on time or on the animal behaviour (i.e. the sipper is electrified after a defined number of licking events have occurred).
The Lickometer controller and software can manage up to 5 animal cages for either rat or mouse; one shocker is required for each cage.
The user-friendly software, provided as standard, manages the system and experimental configuration, collects and saves the experimental data, and provides a detailed report. Data are saved as .csv file and .rpt file (a proprietary format which can be opened only within the Lickometer software)
|Shock||2-Pole Sine-Wave Shocker|
|Test Settings||Trial duration, Initial Pause, Time Intervals, Number of Licks to deliver a shock|
|Data Acquisition||via proprietary software|
|Data Format||Data are saved as .csv file and .rpt file (proprietary to Lickometer software)|
|Operating Temperature||10° to 40°C|
|Pollution Degree||≤ 2|
|Number of Cages||Up to 5 (one shocker for each cage is required)|
35(w)x25(d)x30(h)cm (Rat Cage)
20(w)x24(d)x20(h)cm (Mouse Cage)
8.5Kg (Rat Set-Up)
7.5Kg (Mouse Set-up)
12Kg (Rat Set-Up)
10Kg (Mouse Set-up)
|Packing Dimensions||80x60x44cm (Control Unit, shocker & one cage)|
The Vogel Conflict Test is a conflict based experimental method primarily used in pharmacology. It is used to determine anxiolytic properties of drugs. The Vogel Test predicts drugs that can manage generalized anxiety disorders and acute anxiety states.
Suppressing behaviour through punishment is commonly used to determine the anxiolytic properties of drugs. During the Vogetl Test, animals are receive electrical shocks when trying to get either water. Therefore the number of times the animal goes to get water decreases. When anxiolytic drugs are injected, the number of times animals go up to get water increases, even though the animal are still punished.