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產品資訊

皮質刺激儀 ECT Unit

產品型號: 57800
廠牌名稱: Ugo basile
皮質刺激儀專用於神經化學和神經藥理學研究。恒定的電流能夠確保測量結果有良好的重複性和由藥物對大腦皮層或大腦皮下層區域引起電休克進行精確測定。持續的電流等級通過回饋電路形成,該電路還可調節動物間不同的阻抗。動物阻抗能夠被預測試和顯示,並且在阻抗太高而不能發出理想的電流信號時,會自動警報提示。
角膜和耳使用標準的電極,也可根據實驗人員的需要定制電極。有逆變器、雙相單元、雙極型逆變器可選。

產品特點

The ECT apparatus (Electro Convulsive Therapy) is specially designed for neurochemical and neuropharmacological research. 

A constant current output is used, which ensures reproducible results and accurate determination of the EC threshold while also pinpointing any variations in the threshold brought about by drugs having a specific action on the cortex and sub-cortical regions. The shock parameters have been selected after consulting the most relevant literature, to supply the most suitable range when operating with mice or rats.                                             

Consistent reproducible current levels are produced by feedback circuitry that adjust for variance in impedance of the contact from animal to animal.

The impedance to the animal can be pre-measured and displayed, and a warning signal flashes if the impedance is too great to deliver the desired current level.

The standard auricular electrodes supplied (see main picture) allow a single operator to deliver shock to a number of subjects in a short time. Optional corneal electrodes are available as optional.

The special output circuit enables any type of electrode to be used.

產品規格

General  
Commands via thumb-wheels
Read-out liquid-crystal display
Starting via keys on the electronic unit panel
Power Requirement 115 or 230 V, 50/60 Hz, 75 W max.
Operating Temperature 15° to 30° C
Sound Level < 70 dB (A)
Shock Pulse Train  
Rectangular Positive  Pulses by H.V. Transformer
Constant Current by feedback network
Pulse Rise & Fall Time 20 µs
Pulse Width (ms) 0.1 to 0.9 in 0.1 ms steps ± 1%
Frequency (pulses/s) 1 to 299 in 1 pulse/s steps ± 1%
Shock Duration 0.1 to 9.9 in 0.1 s steps ± 1%
Pulse Voltage max. 2.5 KV
Current Range 1 to 99 mA in 1 mA steps ± 2%
Output Load (at max current) min. 0 Ohm – max. 25 KOhm
KOhm Display 0 to 199 KOhm, 1 KOhm resolution
Physical  
Total Weight 3.42Kg
Shipping Weight 5.0Kg approx.
Dimensions 276(w)x37(d)x13(h)cm
Packing Dimensions 45x34x26cm

應用領域

The ECT Apparatus is specially designed for neurochemical and neuropharmacological research. It is particularly useful for:

  • general screening of potentially neurotropic substances
  • evaluating the depressant or stimulating action of drugs on the CNS
  • endocrinological investigations on the relationship between the nervous sys-tem and the hypophysis.

A constant current output is used which ensures reproducible results and accurate determination of the EC threshold while also pinpointing any variation in the threshold brought about by drugs having specific action on the cortex and subcortical regions.

The shock parameters have been selected after consulting the most recent literature, in order to determinate the range of requirements likely to be needed when operating with mice and rats.

6Hz model: The 6-Hz corneal stimulation model, which was introduced in early fifties, has been recently rediscovered to test alternative approaches for drug-resistant seizures. Accordingly the ketogenic diet, which is known to be a valid treatment for refractory seizures, was found to be effective in counteracting seizures induced by the 6-Hz corneal stimulation. When compared with other models based on electrical stimulation, the 6-Hz paradigm is characterized by the induction of minimally convulsive or non-convulsive seizures with automatized behaviors, defined as “psychomotor seizures”. Ugo Basile ECT Unit performs the 6Hz model conveniently.

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