Ugo basile 主動迴避測試儀 Automatic Reflex Conditioner (Active Avoidance)
Ugo Basile 最新款的主動迴避測試儀在設計時即考量了各種迴避實驗的流程與步驟，外加使用者可以自行調整各項細節，因此可以做到各類型不同的迴避實驗。使用者只需要透過專用的觸控平板系統即可編輯/修改各項實驗參數。
The new model of Active Avoidance Set-Up has been designed to enable the researcher to perform a wide range of avoidance experiments, each according to a flexible schedule.
Via the TIMELINE feature, the user will be able to configure a number of different tests, according to the specific experimental needs, namely the classical shuttle-box tests in its various modes.
The Active Avoidance set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!
Active avoidance is a fear-motivated associative avoidance task. In this task the animal has to learn to predict the occurrence of an aversive event (shock) based on the presentation of a specific stimulus (tone), in order to avoid the aversive event by moving to a different compartment.
The measures recorded include number of avoidances (the mouse crossing to the other compartment during the warning signal), number of non-responses (the mouse failing to cross to the other compartment during the trial), response latency (latency to avoid or escape), number of intertrial responses (i.e., crossing the barrier within the intertrial interval), and serve as an index of learning and allows memory to be assessed.
Ugo Basile Active Avoidance set-up instrument basically consists of a Controller, and a Cage for either rat or mouse. The tests are conducted in a cage, divided into two sections by a partition with an intercommunicating opening at floor level.
The tilting floor ensures a simple and relaible detection mechanism to score the animal’s movement across the two compartments. The electronic unit encompasses all controls for up to 4 cages and a scrambling shocker.
|Touch Screen Controller|
|LCD||12” with resistive touch screen|
|CPU Module Port||2 USB Port 2.0; 1 Ethernet port 10/100Mb;1 DVI port for external monitor|
|Peripheral Port||4 output for Sound, Shock and light; 1 Power supply 12V-2A|
|Expansion Bus Connection||2 RJ11 connectors|
|Shock Intensity||from 0 to 3mA, in 0.1mA steps|
|Shock Duration||in 0.1s|
|Visible Light||0-100, in steps of 5%|
|Sound frequency||100-18.000Hz, in steps of 100Hz|
|Operating Temperature||10° to 40°C|
|Pollution Degree||≤ 2|
|Number of Cages||Up to 4 (with expansion boxes)|
57x27x30(h)cm, I.D. 48x20x22(h) (40532)
47x18x25(h)cm, I.D. 38x9x17(h)cm (40533)
Rat Set-Up 13Kg
Mouse Set-Up 12Kg
|Packing Dimensions||80x60x44cm (Control Unit & one cage)|
Behavioral scientists are well acquainted with avoidance methods that have been used for several decades, originally by psychologists, who were interested in animal behavior.
These procedures were later exploited by neuroscientists, who specifically perform sys-tematic studies of the behavioral changes mainly produced by brain lesions, to define the functions of different C.N.S. sections.
Avoidance tests were soon extended to several other areas of research such as behavior genetics, psychopharmacology and behavioral toxicology. More recently, such use has become routine in animal model studies of aging and of Alzheimer-type dementia, including the search for new drugs of potential therapeutic value, consisting of attenuation of behavioral deficits.