Ugo basile 位置喜好測試箱 Conditioned Place Preference (CPP)
The new Ugo Basile Conditioned Place Preference (CPP) cage is a 2-compartment box to evaluate the abuse potential of substances and the motivational effects of drugs in mice or rats.
The box includes the contextual cues required by the experimental paradigm:
- 4 interchangeable floors with square or circular patterns
- 3 sets of walls
The new CPP box has been designed and optimized for use with any video-tracking software or visual scoring.
The 2 compartments differ for the walls colour and patterns and for the floor patterns and texture.
Both the floors and the wall contexts are interchangeable so that the visual and tactile difference between the 2 compartments can be easily adjusted by the scientist: replaceing the walls is quick and easy, hence on request we can provide customized sets of walls, with different pattern or texture.
|External Dimensions (handles excluded)||
42552 Rat Cage: 63x32x35(h)cm
42553 Mouse Cage: 35x18x29(h)cm
|Internal Dimensions (of each compartment)||
42552 Rat Cage: 30x30x30(h)cm
42553 Mouse Cage: 16x15x25(h)cm
|Patterned Floors||4 interchangeable floors for each cage|
|Context Walls||2 interchangeable context kits provided with each cage (striped and checkered)|
42552 Rat Cage: 22Kg
42553 Mouse Cage: 10Kg
42552 Rat Cage: 80x46x56cm
42553 Mouse Cage: 36x55x45cm
The CPP paradigm provides information on the rewarding or aversive effects of visible and tactile contextual cues associated with drugs.
This technique has acquired great popularity in research studies involving addiction, being much easier, if compared to drug self-administration procedures.
First, the animal is conditioned to identify one of the two compartments with the drug experience. Then the time spent in each compartments is measured; preference or
aversion to the drug-paired compartment, hence rewarding/aversive properties of drugs, can be easily deducted.
The CPP test only requires the animal to carry out a simple operation (i.e. move from one compartment to the other) to approach or avoid the drug-paired compartment; the animal is expected to spend more time in the drug-paired compartment, if the drug experience produced a positive effect.