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PRODUCT

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產品資訊

Blood Pressure Analysis System™ for Mice and Rats非侵入式血壓偵測儀

產品型號: BP-2000
廠牌名稱: Visitech Systems
Visitech BP-2000血壓偵測分析系統是一部電腦化、非侵入式的老鼠尾壓偵測系統。全球已有超過上百家之研究機構採用本系統,是目前應用於基因鼠、基因剔除鼠研究的最好偵測系統,其數據跟一般插管所得之數據最為接近。系統可同時偵測多隻老鼠,並對結果做進一步之群組管理與統計分析。

產品特點

Visitech Systems, Inc.成立於1994年,是全球動物無創血壓分析系統的專業廠商。由2007年諾貝爾​​醫學獎獲得者Oliver Smithies博士與Visitech Systems, Inc.共同研發。 Smithies博士應用BP-2000系列動物無創血壓分析系統測量轉基因老鼠的血壓進行遺傳性高血壓的研究,並於1995年在Hypertension上發表了學術論文。如今全球已有數百個實驗室使用BP-2000系列產品,在各類專業期刊,如《Nature》、《Science》、《Circulation》、《Hypertention》等國際權威雜誌上發表了500多篇論文,在同類產品中處於領先地位。

BP-2000系列動物無創血壓分析系統專門為大、小鼠設計,能快速準確地對大小鼠的心率、收縮壓、舒張壓進行直接測量。測試數據與遙測數據最為接近。技術在同行中是最先進、最權威的。

同類產品用戶最多,發表論文最多。

1、測試參數:收縮壓(SBP)、舒張壓​​(DBP)、心率(HR)、平均壓(MBP);

2、高通量:可提供2通道、4通道、6通道的清醒/麻醉動物測試平台

3、高效率:一次最多可同時測量6隻小鼠、4隻大鼠的血壓,可滿足不同動物模型的測試需求,大大提高了實驗人員的工作效率;

4、可擴展性:根據操作者的實際需要,在原有測試通道的基礎上只需增加動物測試平台,以最經濟的方式滿足實驗的需要

5、動物固定器:10種不同尺寸的固定器,滿足8g-1000g的實驗用鼠的需求。黑暗環境設計,使被測動物順利的進入測量,狀態更為穩定。採用金屬材質,易導熱,結實耐用

6、自動控溫保暖裝置: 低電壓的加熱器位於動物測試平台的下方,足底直接加熱方法,並有溫度傳感器進行控制,保證穩定性和準確性,可以長時間監測大小鼠血壓;溫度可以根據要求調節; 室溫10℃仍能測得血壓。

 

 

產品規格

系統組成:

  • Control Unit
  • Rat/Mice Platform
  • Accessories Kit
  • User’s Guide
  • Optional Notebook Computer
  • Analysis Software License
  • Lifetime Software Upgrades
  • Holders

小鼠Platform分為: 2通道、4通道、6通道

大鼠Platform分為: 2通道、4通道

只要更換Platform就可以更換偵測種類。

Mouse Holders

Part Number

Description

Notes

BP-MH0

Mouse Holder, Size 0

For very small mice

BP-MH1

Mouse Holder, Size 1

For mice under 30 grams

BP-MH2

Mouse Holder, Size 2

For mice 30-45 grams

BP-MH3

Mouse Holder, Size 3

For mice larger than 45 grams

 

Rat Holders

Part Number

Description

Notes

BP-RH1

Rat Holder, Size 1

For rats under 250 grams

BP-RH2

Rat Holder, Size 2

For rats 250-400 grams

BP-RH3

Rat Holder, Size 3

For rats 400-550 grams

BP-RH4

Rat Holder, Size 4

 

BP-RH5

Rat Holder, Size 5

 

BP-RH6

Rat Holder, Size 6

For rats as large as 1 kg

應用領域

Research Papers

More than 500 papers have now been published using data obtained with the BP-2000 Blood Pressure Analysis System™.

In fact, an average about one paper a week is being published. With the BP-2000, you can rest assured that you are working with proven and accepted technology.

 

You can also view lists of only mouse or rat research papers.
 

  Bueno, C. R., Jr; Ferreira, J. C. B.; Pereira, M. G.; Bacurau, A. V. N.; Brum, P. C.
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure
Journal of Applied Physiology, 2010; 109(3): 702.
Keywords: cardiac diseases; muscular abnormalities; treadmill running; Ca2+ transient
 

  Melissa Zack, Boris B. Boyanovsky, Preetha Shridas, William Bailey, Kathy Forrest, Deborah A. Howatt, Michael H. Gelb, Frederick C. de Beera, Alan Daugherty and Nancy R. Webb
Group X secretory phospholipase A2 augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice
Atherosclerosis, 2010; In Press(In Press): In Press.
Keywords: Aneurysm; Atherosclerosis; Inflammation; Interleukins; Metalloproteinases 
 

  Tain, You-Lin; Huang, Li-Tung; Lin, I-Chun; Lau, Ying-Tung; Lin, Ching-Yuang
Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats
Journal of Pineal Research, 2010; Online(Online): Online.
Keywords: asymmetric dimethylarginine;hypertension;melatonin;nitric oxide;oxidative stress 
 

  Felicitas L. Princz-Kranz, Thomas Mueggler, Marlen Knobloch, Roger M. Nitsch and Markus Rudin
Vascular response to acetazolamide decreases as a function of age in the arcAß mouse model of cerebral amyloidosis
Neurobiology of Disease, 2010; 40(1): 284-292.
Keywords: Acetazolamide; Alzheimer’s disease (AD); Cerebral amyloid angiopathy (CAA); Cerebral blood volume (CBV); Functional magnetic res 
 

  Groleau, Jessika; Dussault, Sylvie; Haddad, Paola; Turgeon, Julie; Menard, Catherine; Chan, John S.; Rivard, Alain
Essential Role of Copper-Zinc Superoxide Dismutase for Ischemia-Induced Neovascularization Via Modulation of Bone Marrow-Derived Endothelial Progenitor Cells
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; Online(Online): Online.
Keywords: CuZnSOD • endothelial progenitor cells • neovascularization • oxidative stress 
 

  Oxenkrug, Gregory F.; Summergrad, Paul
Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats
Annals of the New York Academy of Sciences, 2010; 1199: 114-120.
Keywords: Ramelteon;melatonin;hypertension;weight gain;aging;age;spontaneously hypertensive rats;metabolic syndrome;age-associated neuroen 
 

  Yinxing Liu, Christa Studzinski, Tina Beckett, M. Paul Murphy, Ronald L. Klein and Louis B. Hersh
Circulating neprilysin clears brain amyloid
Molecular and Cellular Neuroscience, 2010; 45(2): 101-107.
Keywords: Neprilysin; Alzheimer’s disease; Gene therapy; Adeno-associated virus; Amyloid beta peptide 
 

  Yun-Wen Chen, Isabelle Chenier, Stella Tran, Michael Scotcher, Shiao-Ying Chang and Shao-Ling Zhang
Maternal diabetes programs hypertension and kidney injury in offspring
Pediatric Nephrology, 2010; 25(7): 1319-1329.
Keywords: Offspring - Maternal diabetes - Hypertension - Kidney injury 
 

  Gayen, Jiaur R.; Zhang, Kuixing; RamachandraRao, Satish P.; Mahata, Manjula; Chen, Yuqing; Kim, Hyung-Suk; Naviaux, Robert K.; Sharma, Kumar; Mahata, Sushil K.; O’Connor, Daniel T.
Role of Reactive Oxygen Species in Hyper-Adrenergic Hypertension: Biochemical, Physiological, and Pharmacological Evidence from Targeted Ablation of the Chromogranin A (Chga) Gene
Circulation: Cardiovascular Genetics, 2010; Online(Online): Online.
Keywords: hypertension • nitric oxide • Chromogranin A • reactive oxygen species 
 

  Touati S, Meziri F, Devaux S, Berthelot A, Touyz RM, Laurant P.
Exercise Reverses Metabolic Syndrome in High Fat Diet-Induced Obese Rats
Medicine & Science in Sports & Exercise, 2010; Online(Online): Online. 
 

  Jankowski, Marek; Wang, Donghao; Danalache, Bogdan; Gangal, Marius; Gutkowska, Jolanta
Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats
AJP - Heart and Circulatory Physiology, 2010; 299(2): H265.
Keywords: oxytocin receptor; ovariectomy; hypertrophy; genistein 
 

  Alonso, Florian; Krattinger, Nathalie; Mazzolai, Lucia; Simon, Alexander; Waeber, Gérard; Meda, Paolo; Haefliger, Jacques-Antoine
An angiotensin II- and NF-?B-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension
Cardiovascular Research, 2010; Online(Online): Online.
Keywords: Gap junctions Cx37 Cx40 Cx43 Cx45 Aorta Arteries Angiotensin II Renin NF-?B Transgenic mice Hypertension 
 

  Zhang, Rongxin; Zhang, Yuan Yuan; Huang, Xiao R.; Wu, Yin; Chung, Arthur C.K.; Wu, Ed Xuekui; Szalai, Alexander J.; Wong, Benjamin C.Y.; Lau, Chu-Pak; Lan, Hui Y.
C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II-Induced Hypertensive Cardiac Disease
Hypertension, 2010; 55(4): 953.
Keywords: CRP • hypertension • angiotensin II • cardiac fibrosis • inflammation • TGF-ß/Smads 
 

  Gou-Chun Chen, Chun-Yin Huang, Mei-Yu Chang, Chi-Hua Chen, Shiow-Wen Chen, Ching-jang Huang and Pei-Min Chao
Two unhealthy dietary habits featuring a high fat content and a sucrose-containing beverage intake, alone or in combination, on inducing metabolic syndrome in Wistar rats and C57BL/6J mice
Metabolism, 2010; Online(Online): Online. 
 

  Enza Palazzo, Maria Grazia Rimoli, Maria De Chiaro, Francesca Guida, Daniela Melisi, Annalisa Curcio, Vito de Novellis, Ida Marabese, Francesco Rossi, Enrico Abignente and Sabatino Maione
Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect
Neuropharmacology, 2010; 58(3): 660-667.
Keywords: Imidazo[1,2-b]pyridazine; Inflammatory pain; PAG; RVM; Ethosuximide 
 

  Alan Daugherty, Debra L. Rateri, Israel F. Charo, A. Phillip Owens III, Deborah A. Howatt and Lisa A. Cassis
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
Clinical Science, 2010; 118: 681-689.
Keywords: angiotensin, aneurysm, aorta, chemokine, elastin, macrophage 
 

  Huang, Xiao R.; Chung, Arthur C.K.; Yang, Fuye; Yue, Wensheng; Deng, Chuxia; Lau, Chu Pak; Tse, Hung Fat; Lan, Hui Y.
Smad3 Mediates Cardiac Inflammation and Fibrosis in Angiotensin II-Induced Hypertensive Cardiac Remodeling
Hypertension, 2010; 55(5): 1165.
Keywords: hypertension • cardiac remodeling • TGF-ß, Smad3 • angiotensin II 
 

  Firas Younis, Naftali Stern, Rona Limor, Yoram Oron, Sarah Zangen and Talma Rosenthal
Telmisartan ameliorates hyperglycemia and metabolic profile in nonobese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activator receptor–? activation
Metabolism, 2010; In Press(In Press): In Press. 
 

  Christophe Guilluy, Jeremy Bregeon, Gilles Toumaniantz, Malvyne Rolli-Derkinderen, Kevin Retailleau, Laurent Loufrani, Daniel Henrion, Elizabeth Scalbert, Antoine Bril, Raul M Torres, Stephan Offermanns, Pierre Pacaud, Gervaise Loirand
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure
Nature Medicine, 2010; 16(2): 183. 
 

  Xu, Jiang; Carretero, Oscar A; Liao, Tang-Dong; Peng, Hongmei; Shesely, Edward Glen; Xu, Junxiao; Liu, Thomas S; Yang, James J.; Reudelhuber, Tim L; Yang, Xiao-Ping
Local Angiotensin II Aggravates Cardiac Remodeling in Hypertension
AJP - Heart and Circulatory Physiology, 2010; Online(Online): ajpheart.00538.2010v1.
Keywords: Inflammation; oxidative stress; heart; hypertrophy 
 

  Dilauro, Marc; Zimpelmann, Joseph; Robertson, Susan June; Genest, Dominique; Burns, Kevin D.
The Effect of ACE2 and Angiotensin-(1-7) in a Mouse Model of Early Chronic Kidney Disease
AJP - Renal Physiology, 2010; Online(Online): Online.
Keywords: renin-angiotensin system; 5/6 nephrectomy; albuminuria 
 

  Vaingankar SM, Li Y, Biswas N, Gayen J, Choksi S, Rao F, Ziegler MG, Mahata SK, O’connor DT
Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses
J Hypertens, 2010; Online(Online): Online. 
 

  Vaingankar, Sucheta M.; Li, Ying; Corti, Angelo; Biswas, Nilima; Gayen, Jiaur; O’Connor, Daniel T.; Mahata, Sushil K.
’Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout’
Physiological Genomics, 2010; 41(1): 91.
Keywords: blood pressure; catecholamine; stress; hypertension; chromogranin A; bacterial artificial chromosome 
 

  Firas Younis, David Mirelman, Aharon Rabinkov, Talma Rosenthal
S-Allyl-Mercapto-Captopril: A Novel Compound in the Treatment of Cohen-Rosenthal Diabetic Hypertensive Rats
The Journal of Clinical Hypertension, 2010; Online(Online): Online. 
 

  Yoshida, Tadashi; Semprun-Prieto, Laura; Sukhanov, Sergiy; Delafontaine, Patrick
IGF-1 prevents Ang II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase Atrogin-1 expression
AJP - Heart and Circulatory Physiology, 2010; Online(Online): 00146.2010v1. 
 

  Jia, Zhanjun; Yang, Tianxin
mPGES-1 Deletion Impairs Aldosterone Escape and Enhances Sodium Appetite
AJP - Renal Physiology, 2010; Online(Online): ajprenal.90702.2008v1.
Keywords: Aldosterone escape; mPGES-1; PGE2; proximal tubule 
 

  u-Lin Tain, Chih-Sung Hsieh, I-Chun Lin, Chih-Cheng Chen, Jiunn-Ming Sheen and Li-Tung Huang
Effects of maternal l-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway
Nitric Oxide, 2010; In Press(In Press): In Press.
Keywords: Asymmetric dimethylarginine; Citrulline; Hypertension; Kidney disease; Nitric oxide 
 

  Susanne B Nicholas, Joey Liu, Jason Kim, Yuelan Ren, Alan R Collins, Lam Nguyen, Willa A Hsueh
Critical role for osteopontin in diabetic nephropathy
Kidney International, 2010; 77(7): 588. 
 

  Stewart, Corrine R. MD; Landseadel, Jessica P. BS; Gurka, Matthew J. PhD; Fairchild, Karen D. MD, FAAP
Hypothermia increases interleukin-6 and interleukin-10 in juvenile endotoxemic mice
Pediatric Critical Care Medicine, 2010; 11(1): 109-116. 
 

  Kosugi, Tomoki; Heinig, Marcelo; Nakayama, Takahiro; Matsuo, Seiichi; Nakagawa, Takahiko
eNOS Knockout Mice with Advanced Diabetic Nephropathy Have Less Benefit from Renin-Angiotensin Blockade than from Aldosterone Receptor Antagonists
American Journal of Pathology, 2010; 176(2): 619. 
 

  Nakayama, Takahiro; Sato, Waichi; Yoshimura, Ashio; Zhang, Li; Kosugi, Tomoki; Campbell-Thompson, Martha; Kojima, Hideto; Croker, Byron P.; Nakagawa, Takahiko
Endothelial von Willebrand Factor Release Due to eNOS Deficiency Predisposes to Thrombotic Microangiopathy in Mouse Aging Kidney
American Journal of Pathology, 2010; Online(Online): Online. 
 

  Jia, Zhanjun; Aoyagi, Toshinori; Yang, Tianxin
mPGES-1 Protects Against DOCA-Salt Hypertension via Inhibition of Oxidative Stress or Stimulation of NO/cGMP
Hypertension, 2010; 55(2): 539.
Keywords: cGMP • DOCA-salt hypertension • mPGES-1 • nitric oxide • oxidative stress 
 

  McCalmon, Sarah A.; Desjardins, Danielle M.; Ahmad, Saad; Davidoff, Katharine S.; Snyder, Christine M.; Sato, Kaori; Ohashi, Koji; Kielbasa, Ondra M.; Mathew, Matthen; Ewen, Elizabeth P.; Walsh, Kenneth; Gavras, Haralambos; Naya, Francisco J.
Modulation of Angiotensin II-Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2
Circulation Research, 2010; 106(5): 952.
 

  Chrissobolis, Sophocles; Faraci, Frank M.
Sex Differences in Protection Against Angiotensin II-Induced Endothelial Dysfunction by Manganese Superoxide Dismutase in the Cerebral Circulation
Hypertension, 2010; 55(4): 905.
Keywords: genetically altered mice • cerebral arteries • mitochondria • oxidative stress
 

  Bagnost, Teddy; Ma, Ling; da Silva, Rafaela F.; Rezakhaniha, Rana; Houdayer, Christophe; Stergiopulos, Nikos; André, Claire; Guillaume, Yves; Berthelot, Alain; Demougeot, Céline
Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension
Cardiovascular Research, 2010; Online(Online): Online.

 

原廠連結:

http://www.visitechsystems.com/

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