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產品資訊

大小鼠全自動行為偵測判定分析系統 METRIS LABORAS

產品型號:
廠牌名稱: Metris
完全自動化的小型囓齒類實驗動物的行為分析系統。
獨特的振動技術。
能夠取得小鼠和大鼠的行為及軌跡訊息。 
可進行長時間的紀錄。
可以同時自動執行8個獨立鼠籠的行為評估。 
獨立的光照條件。 
能夠識別刻板行為。 
一站式服務。

產品特點

Normal behaviors

Rats and Mice

Group 1 (basic)
  • Climbing (mice only)
  • Locomotion
  • Immobility
  • Rearing
Group 2 (advanced)
  • Grooming
  • Drinking
  • Eating

Special Behaviors

Rats
  • Hindlimb licking
    (Formalin test)
  • Scratching
  • Wet Dog Shakes (WDS)
  • Head shakes
  • Head twitches
  • Purposeless chewing
Mice
  • Scratching
  • Seizures: Barrel rolls &
    Tonic Clonic
  • Seizures: Racine scale
    P4 & P5
  • Freezing
  • Startle response

Tracking information

Rats and Mice

Position tracking info
  • Position (X,Y)
  • Speed
  • Avg. speed
  • Max. speed
  • Time of max. speed
  • Traveled distance
  • Position distribution
Circling info
  • Nr. of circles (CW and CCW)
  • Avg. time in circle
  • Avg. speed in circle
  • Avg. circle size

How does it Work?

new platf

LABORAS is based on vibration and force signal analysis to determine both the behavior and the position of the animal. To provide reliable behavioral scores which have a high correlation with human observations a combination of dedicated mechanics, electronics and software was developed. The basis of the system are the measurement platforms, which convert the movements of the animal into electrical signals. The cage with the animal is placed and hold at a fixed position on the measurement platform. The triangular shaped platforms consist of:

  • a heavy "Corian" baseplate in which the force transducers are mounted
  • a very light weight and stiff "Carbon Fibre" measurement plate which is positioned on the top of the transducers
  • a construction that holds the upper part of the cage.

The vibrations evoked by the movements of the animal are picked up by the carbon fibre measurement plate and passed to the force transducers below it. The transducers are connected to a pre-amplifier (and signal conditioning unit), which is mounted in the measurement platform.

electronics.gif The gain and offset of the pre-amplifier are adjusted based on the weight of the laboratory animal that is entered by the experimenter. To eliminate difficult and time consuming manual settings of the amplifiers all gain and offset adjustments are performed by the software through a simple calibration routine. The pre amplifier also takes care for the proper filtering of the signals.
Laboras Control UnitThe output signals of the amplifiers are send to the LABORAS Control Unit (LCU), which converts the analog signals into a digital format. The LABORAS Control Unit can handle the signals of up to eight measurement platforms. The LCU sends the data over a serial line to the PC for further processing.

Transducer signals vs. behaviors

The processing of the vibration signals forms the heart of the software. The LABORAS software uses the latest pattern recognition and signal analysis techniques to reliably recognize a number of behaviors of rats and mice. Each behavior has its own unique signature of signal characteristics which can be detected by the LABORAS software to identify a behavior. This is illustrated for a couple of behaviors in the picture on the right, such as grooming, eating, drinking. In addition to the behaviors detected by LABORAS, the software is also able to extract the position of the animal and various other tracking details from the transducer signals, such as speed, position distribution and circles clockwise and counter clockwise.

 

LABORAS Advantages

 

LABORAS provides a number of advantages over other systems due to its unique technology which is based on vibration analysis.

  • Non-invasive (no wires or implants):

    the animal can move freely and is not influenced by the system in any way.
  • capable of obtaining behavior and tracking information of both mice and rats.
  • long term tests:
    measures uninterrupted for up to 7 days.
  • automates the behaviour scoring of up to 8 solitary housed animals at the same time.
  • independent of light conditions:
    measures in dark and under all light conditions.
  • Capable of recognizing stereotyped behaviors:
    like: wet dog shakes, tremors, skin twitches , convulsions, scratching, etc.
  • "one stop shop"
    provides all information using a single technique/system

LABORAS for Windows

產品規格

Laboras Specifications

LABORAS is designed for and with the help of laboratory animal researchers, which has resulted in a system that is easy to use and matches your research needs.

Below we have summarized the main functions and performance of the Laboras equipment. Laboras is a modular system, so it is possible to configure the system with different combinations of functions and to upgrade the system at a later moment.

 

 

Standard Behavior detection functionality

  • Resting (immobility):
    Movements are absent while the animal is in a sitting or lying position.
    Very short movements (e.g. turning over while sleeping ) are not considered as an interruption.
  • Locomotion:
    Activities such as walking, running, jumping.
  • Rearing (rats only):
    The animal is standing upright on its hind legs (mostly against a side wall of the cage).
  • Eating:
    The animal eats food pellets while standing upright, gripping the bars of the food hopper or the climbing grid in the enriched cages. While the animal is climbing or hanging, the hind legs or tail may touch the floor or side wall of the cage.
  • Drinking:
    The animal stands upright gripping the water bottle and licking water.
  • Grooming:
    The animal is shaking, scratching, wiping or licking its fur, snout, ears, tail or genitals.
  • Climbing (mouse only):
    Climbing and hanging on the bars of the wire cage lid or food hopper or on the climbing grid in the enriched cages. While the animal is climbing or hanging, the hind legs or tail may touch the floor or side wall of the cage.
  • Undefined:
    All behaviours not classified in one of the previous categories.

 

Tracking functionality

  • Position:
    The position of the animal relative to the center of the cage. (resolution = 1 mm; accuracy better than 5 mm)
  • Distance traveled:
    The total distance traveled by the animal during the test. (resolution = 1 cm; accuracy better than 10 cm/hr)
  • Maximum speed:
    The highest velocity of the animal during the test. (resolution = 0.1 cm/s; accuracy better than 0.5 cm/s)
  • Position distribution:
    Graphical presentation showing the preference of the animal for certain spots.
  • Circling: NEW!
    Number of circles (clockwise and counter clockwise) that the animal makes during test. Two types of circling are scored "wide circling" and "turning around the axis". In addition average diameter of circle, average time in circle, average speed in circle are calculated.

Special Behavior detection functionality

  • Scratching (in mice and rats): NEW!
    Repetitive fast movement of the hindlimb, rubbing the side of the body, neck and face.
    Spontaneous scratching epsisodes are generally shorter than a second. Drug induced scratching or scratching because of skin diseases can last for seconds or even minutes.
  • Purposeless Chewing (in rats)
    Chewing movements in the absence of food. Generally consisting of large chewing movements (head moving) and small chewing movements (lip movement only)
  • Hindlimb licking (in rats) - Formalin Test
    The animal licks the hindlimb as a pain response to a formalin injection in the hindlimb. The three phase response consisting of Phase-I, Q(uiet)-phase and Phase-II are accurately determined by LABORAS.
  • Wet Dog Shakes (in rats)
    A paroxysmic or quivering shudder of the trunk (body) up to the shoulders of the rat, consisting of a series of radial movements of the body, during which the trunk rotates along the center axis of the body. The quivering shudder seems to roll over the body of the animal from the shoulder to the tail.
    Depending of the intensity and type of WDS the quivering shudder sometimes extends beyond the shoulder of the animal, including the neck and sometimes the head.
  • Seizures (in mice)
    Several types of strong seizures can be detected. Amongst others: Barrel roll seizures, tonic clonic seizures and seizures P4 and P5 (scored on the Racine scale).
  • Freezing (in mice) - Fear conditioning test: NEW!
    The animal exhibits complete motionless behavior (only autonomous processes such as breathing and heartbeat are present). Freezing is often related to fear and anxiety and such is often use for fear conditioning tests.
  • Startle response (in mice) - Fear conditioning test: NEW!
    an involuntary reaction to a sudden unexpected stimulus (especially a loud sound); involves flexion of most skeletal muscles and a variety of visceral reactions. Startle is often related to fear and anxiety and such is often use for fear conditioning tests.

 

User Interface

  • GLP compatible user interface and data management The software complies to the GLP requirements for software used in laboratory instruments
  • Easy to use interface:
    Straight forward user interface with pull-down menus and experiment navigation tree
  • extensive and complete experiment data administration
    All experiment data can be entered in the administration software module of LABORAS. The experiment data is added to the test results. Test sessions and related data being part of one experiment can be kept together in one experimental design.

Output definitions

  • time tagged behaviour files and position files
  • test result summaries over user definable windows:
    Including Behavior Durations and Behavior Frequencies
  • export of test results in several commonly used formats:
    MS-Excel, SPSS, SAS/JMP, etc.

應用領域

2012

bullet2.gif Castagné, V.; Wolinsky, T.; Quinn, L.; Virley, D.
Differential behavioral profiling of stimulant substances in the rat using the LABORAS™ system
Pharmacology, biochemistry, and behavior, March 2012 Abstract
bullet2.gif Waters, K.A.; Stean, T.O.; Hammond, B.; Virley, D.J.; Upton, N.; Kew, J.N.C.; Hussain, I.
Effects of the selective 5-HT7 receptor antagonist SB-269970 in animal models of psychosis and cognition
Behavioural Brain Research, Volume 228, Issue 1, 1 March 2012, Pages 211-218 Abstract
bullet2.gif Schutová, B.; Hrubá, L.; Rokyta, R.; Šlamberová, R.
Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood
Developmental Psychobiology, 23 Feb. 2012, Pages xx Abstract

2011

bullet2.gif Krieger, M.
The hematopoietic cytokine Granulocyte - Macrophage Colony Stimulating Factor is involved in cognitive processing
Dessertation University of Heidelberg, Germany, October 2011 Full article
bullet2.gif Srinivasan, J.; Wright, R.L.; Roberts, J.; MacSweeney, C.; Marston, H.M.
Ketamine-induced Behavioural and Neurochemical Effects: Simultaneous Measurements of Locomotor Activity, Extracellular Cortical Glutamate and Drug Levels in C57 Mice
Poster at SFN2011 of Merck, New House, UK, October 2011 Poster
bullet2.gif Cazzin, C.; Piccoli, L.; Massagrande, M.; Garbati, N.; Michielin, F.; Knaus, H.G.; Ring, C.J.A.; Morrison, A.D.; Merlo-Pich, E. Rovo, Z.; Astori, S.; Lüthi, A.; Corti, C. and M. Corsi†
rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal
Genes, Brain and Behavior, Volume xxx, pp xxx; (July 11, 2011) Full Article
bullet2.gif Metris
Inside View feature about Laboras of Metris b.v.
Nature Magazine, 7 July 2011 Full article
bullet2.gif Šlamberová, R.; Yamamotová, A.; Schutová, B.; Hrubá, L.; Pometlová, M.
Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats
Prague Medical Report, Vol. 112 (2011) No. 2, p. 102–114 Full article
bullet2.gif Wolinsky, T.; Quinn, L.; Virley, D.; Castagné, V.; Moser, P.
Behavioral profiling of stimulant after acute administration in rats using Laboras
Poster at "College on Problems of Drug Dependence" (CPDD), June 18-23, 2011 Poster
bullet2.gif Lynch III, J.J.; Castagné, V.; Moser, P.C.; Mittelstaft, S.W.
Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies
Journal of Pharmacological and Toxicological Methods, Volume xxx, pp xxx; (March 31, 2011) Full article
bullet2.gif Razzoli, M.; Carboni, L.; Andreoli, M.; Ballottari, A.; Arban, R.
Different susceptibility to social defeat stress of BalbC and C57BL6/J mice
Behavioural Brain Research, Volume 216, pp 100–108 (1 January 2011) Full article

2010

bullet2.gif Zambello, E.; Zanetti, L.; Hédou, G.F.; Angelici, O.; Arban, R.; Tasan, R.O.; Sperk G.; Caberlotto, L.
Neuropeptide Y-Y2 receptor knockout mice: influence of genetic background on anxiety-related behaviors
Neuroscience, "Article in Press" (available online 3 November 2010) Full article
bullet2.gif Razzoli, M.; Carboni, L.; Andreoli, M.; Maraia, G.; Di Francesco, C.; Arban, R.
Functional role of calcium-stimulated Adenylyl Cyclase 8 in adaptations to psychological stressors in the mouse: Implications for mood disorders
Neuroscience, Volume 170, pp 429-440 (2010) Full article
bullet2.gif Dawe, G.S.; Nagarajah, R.; Albert, R.; Casey, D.E.; Gross, K.W.; Ratty, A.K.
Antipsychotic drugs dose-dependently suppress the spontaneous hyperactivity of the chakragati mouse
Neuroscience 171 (2010) 162–172 (available online 17 September 2010) Full article
bullet2.gif Broide, R.S.; Ardilla, C.; Aoki, K.R.; Francis, J.
The LABORAS behavioral assay provides an alternative, non-lethal experimental method for the assessment of botulinum toxin systemic safety
Poster at the Society for Neuroscience conference, SFN 2010 (13-17 November 2010) Abstract of Poster
bullet2.gif Schutová, B.; Hrubá, L.; Rokyta, R.; Slamberová, R.
Sensitivity to methamphetamine in adulthood is increased in rats prenatally exposed to the same drug
Poster at the Society for Neuroscience conference, SFN 2010 (13-17 November 2010) Poster
bullet2.gif Slamberová, R.; Yamamatová, A.; Hrubá, L.; Schutová, B.; Rokyta, R.
Prenatal methamphetamine exposure alters the effect of methamphetamine and cocaine challenge dose on behavior and nociception in adult male rats
Poster at the Society for Neuroscience conference, SFN 2010 (13-17 November 2010) Poster
bullet2.gif Dawe, G.S.; Albert, R.; Ratty, K.
Home cage activity monitoring reveals changes in circadian rhythm in the chakragatimouse model of aspects of schizophrenia
Poster at the Society for Neuroscience conference, SFN 2010 (13-17 November 2010) Poster
bullet2.gif Das, R.; Plaas, A.; Sandy, J.D.; Li, J.; Tortorella, M.D.; Malfait, A.M.
Destabilization of the medial meniscus as a model for dissecting pain pathways associated with development of murine osteoarthritis
Poster at 13th World Congress on Pain, IASP 2010 (1 September 2010) Abstract of Poster
bullet2.gif Dahllöf, H.; Sederholm, F.; Halvarsson, L.; Täpp, V.; Jongsma Wallin, H.; Stenfors, C.
Pharmacological Characterisation of the Behavioral Registration System Laboras in the Detection of Formalin-Induced Nociception
Poster at 13th World Congress on Pain, IASP 2010 (1 September 2010) Poster
bullet2.gif Lightowler, S.; Barratt, L.; Kennett, G.
LABORAS, An automated measure of formalin paw licking behaviour and concurrent locomotor activity in rats
Poster at 13th World Congress on Pain, IASP 2010 (31 August 2010) Poster
bullet2.gif Wong, F.; Lee, S.H.; Atcha, Z.; Ong, A.B.O.; Pemberton, D.J.; Chen, W.
Rasagiline improves learning and memory in young healthy rats
Behavioural Pharmacology, Volume 21, Issue 4, pp 278-282 (2 July 2010) Full article
bullet2.gif Glynn, D.; Gibson, H.E.; Harte, M.K.; Reim, K.; Jones, S.; Reynolds, G.P.; Morton, A.J.
Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse
Human Molecular Genetics, Volume 19, Issue 17, pp 3402–3412 (28 June 2010) Full article
bullet2.gif McCann, F.E.; Palfreeman, A.C.; Andrews, M., Inglis, J.J.; Schafer, P.; Feldmann, M.; Williams, R.O.; Brennan, F.; Perocheau D.P.
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
Arthritis Research & Therapy 2010, 12:R107, (June 2, 2010) Full article
bullet2.gif Chen, S.K..; Tvrdik, P.; Peden, E.; Cho, S.; Wu, S.; Spangrude, G.; Capecchi, M.R.
Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice
Cell 141, Pages 775-785 (May 28, 2010) Full article
bullet2.gif Akcali, D.; Sayin1, A.; Sara, Y.; Bolay, H.
Does single cortical spreading depression elicit pain behaviour in freely moving rats?
Cephalalgia Volume .., Issue .., Pages 1-12 (March 31, 2010) Full article

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